Donor-derived Cell-free DNA Kinetics Post-kidney Transplant Biopsy
نویسندگان
چکیده
منابع مشابه
Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype
Quantification of cell-free DNA (cfDNA) in circulating blood derived from a transplanted organ is a powerful approach to monitoring post-transplant injury. Genome transplant dynamics (GTD) quantifies donor-derived cfDNA (dd-cfDNA) by taking advantage of single-nucleotide polymorphisms (SNPs) distributed across the genome to discriminate donor and recipient DNA molecules. In its current implemen...
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Background: Previous studies have demonstrated that donor-derived cell-free DNA (dd-cfDNA) found in circulating blood of transplant recipientsmay serve as a noninvasive biomarker of allograft rejection. To better interpret the clinicalmeaning of dd-cfDNA, it is essential to understand the biological variation of this biomarker in stable healthy recipients. This report establishes the biological...
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women (28 mL/kg). Serum erythropoietin level was repeated and was found to have decreased below normal at 3.0 mU/mL. A diagnosis of PV was made, and a therapeutic phlebotomy was initiated. To date, the patient has undergone 38 therapeutic phlebotomies during a 6-year period, and the patient continues with elevated hemoglobin concentrations and platelet counts. Her symptoms are well controlled, ...
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Program in Dermatopathology, Department of Pathology, Brigham andWomen’s Hospital, Harvard Medical School, Boston, MA, USA, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Division of Dermatopathology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA and Department of Dermatology, Brigham andWomen’s Hospital, Harva...
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We report the rare occurrence of donor-derived myeloid sarcoma in two kidney transplant patients who received organs from a single deceased donor. There was no evidence of preexisting hematologic malignancy in the donor at the time of organ recovery. Both recipients developed leukemic involvement that appeared to be limited to the transplanted organ. Fluorescence in situ hybridization (FISH) an...
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ژورنال
عنوان ژورنال: Transplantation Direct
سال: 2021
ISSN: 2373-8731
DOI: 10.1097/txd.0000000000001149